Jan Marini recommended usage from 1 to 4 times a week, depending on skin sensitivity. Directions: Apply Skin Zyme in a thin even layer over entire face and neck, allow to remain for up to 20 minutes. To remove Skin Zyme, apply a small amount of Clean Zyme to face and massage gently. Remove with a washcloth. Splash face 10 to 15 times with lukewarm water. Pat dry.